Sutradara: Tom McGrath
Musik digubah oleh: Hans Zimmer
Perusahaan produksi: DreamWorks Animation
Cerita oleh: Marla Frazee
A teenager named Tim Templeton (Tobey Maguire) his seven-year-old life (Miles Bakshi) being jealous of his fast-talking, briefcase-carrying baby brother named the "Baby Boss" (Alec Baldwin). When he goes on a mission to win back affection of his parents (Jimmy Kimmel and Lisa Kudrow), he finds out about a secret plot by Puppy Co.'s CEO Francis E. Francis (Steve Buscemi) which revolves around his baby brother and threatens to destabilize the balance of love in the world. Both brothers must unite to save their parents and restore order to the world and prove that love is indeed an infinite force.